PDRN treatment and polynucleotide treatment are aesthetic procedures used for certain skin concerns. They use products made from DNA-derived materials. PDRN and PN are closely related, but thinking they are the same can be a wrong suggestion. Knowing the difference can help patients understand the treatment options more clearly.
PDRN means polydeoxyribonucleotide; it is a DNA-derived material. PN means polynucleotides, which are closely related DNA-derived materials. Both are commonly made from highly purified fish-derived DNA. This is why the term salmon DNA treatment is often used.
PDRN and PN can differ in their molecular structure. Their chain length and concentration can also vary. Commercial skin boosters may contain other ingredients as part of the formulation.
No. PDRN treatment is different from a conventional dermal filler.
Dermal fillers are generally used to restore lost volume or change facial contour. PDRN and PN treatments focus on the condition and appearance of the skin. They are therefore used for a different treatment purpose.
PDRN treatment has been studied for its role in body processes linked with tissue repair. Polynucleotides are also used in aesthetic medicine to support the skin environment. Research has looked at how these materials affect skin cells involved in repair. It has also studied their effect on structures that help support the skin.
Results do vary, as it depends from person to person. PDRN treatment should not be described as reversing ageing or as a treatment that guarantees collagen production.
PDRN and polynucleotide treatments may be considered for skin hydration, surface texture and fine superficial lines. Some formulations contain ingredients that help the skin hold moisture. These may be useful when the skin appears dry or less supple.
A carefully selected PDRN under-eye treatment or PN option may also be considered for crepey skin around the eyes. Under-eye pigmentation has a different cause from tear-trough hollowing. Skin laxity is another separate concern. These problems may need different treatment approaches.
MedLinks compares each product by looking at its formulation and intended use. Skin boosters are not treated as if they are all the same.
Elaxen PN is a polynucleotide-based skin booster, and PN is its main active component. Its PN-focused formulation makes it different from products based on c-PDRN.
Rejuran Skin Booster is based on c-PDRN. It also contains hyaluronic acid and amino acids. This gives it a different formulation from Elaxen PN.
Klardie is a range of professional skin booster solutions. Some Klardie formulations contain PDRN as part of a wider ingredient complex. The exact product and its intended method of use should therefore be confirmed before treatment.
A consultation first checks whether PDRN treatment, polynucleotide treatment or another skin rejuvenation treatment is suitable. The dermatologist reviews the treatment area and relevant medical history. The patient’s desired result is also discussed.
The clinician then explains which formulation has been selected and how it will be used. The proposed treatment course is discussed at this stage. The number of sessions is not the same for every patient or product. It is decided as part of the individual treatment plan.
People with an active skin problem or a relevant allergy should discuss suitability before PDRN treatment. Pregnancy or breastfeeding should also be mentioned before treatment.
Tell the dermatologist about medicines and medical conditions that may affect the plan. Previous reactions to aesthetic procedures are also important. If you have a fish or seafood allergy, mention it before considering a fish-derived PDRN or PN product.
Recovery after PDRN treatment depends on the product, treatment area and technique used.
Redness or mild swelling may occur for a short time. Some patients may also notice tenderness or bruising. Small raised areas can appear where treatment has been given. If the procedure breaks the skin, infection is a less common but relevant risk.
PDRN treatment results usually develop over time. The results do not appear suddenly.
The response can differ between patients. The starting condition of the skin can affect the outcome. The formulation used can also influence the result. A dermatologist can give more relevant expectations after examining the treatment area.
MedLinks was founded by AIIMS-trained dermatologists. It provides aesthetic care within a clinical dermatology practice.
Patients considering PDRN skin boosters or PN treatments can therefore access medical skin expertise alongside aesthetic treatment options. This allows newer procedures to be considered as part of wider dermatological care rather than as stand-alone product trends.
Dr Pankaj Chaturvedi, who is the co-founder of MedLinks, holds an MBBS and MD in Dermatology from AIIMS, New Delhi. His background in clinical and aesthetic dermatology reflects MedLinks. Our treatments, such as PDRN and PN skin boosters, are considered according to individual skin concerns and treatment suitability.
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